Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6374
pubmed:dateCreated
1992-6-11
pubmed:abstractText
Glutamate application at synapses between hippocampal neurons in culture produces long-term potentiation of the frequency of spontaneous miniature synaptic currents, together with long-term potentiation of evoked synaptic currents. The mini frequency potentiation is initiated postsynaptically and requires activity of NMDA receptors. Although the frequency of unitary quantal responses increases strongly, their amplitude remains little changed with potentiation. Tests of postsynaptic responsiveness rule out recruitment of latent glutamate receptor clusters. Thus, postsynaptic induction can lead to enhancement of presynaptic transmitter release. The sustained potentiation of mini frequency is expressed even in the absence of Ca2+ entry into presynaptic terminals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
357
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
134-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1349728-6-Cyano-7-nitroquinoxaline-2,3-dione, pubmed-meshheading:1349728-Animals, pubmed-meshheading:1349728-Animals, Newborn, pubmed-meshheading:1349728-Calcium, pubmed-meshheading:1349728-Cells, Cultured, pubmed-meshheading:1349728-Evoked Potentials, pubmed-meshheading:1349728-Glutamates, pubmed-meshheading:1349728-Glutamic Acid, pubmed-meshheading:1349728-Hippocampus, pubmed-meshheading:1349728-Kinetics, pubmed-meshheading:1349728-Magnesium, pubmed-meshheading:1349728-Membrane Potentials, pubmed-meshheading:1349728-Neurons, pubmed-meshheading:1349728-Pyramidal Tracts, pubmed-meshheading:1349728-Quinoxalines, pubmed-meshheading:1349728-Rats, pubmed-meshheading:1349728-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:1349728-Synapses, pubmed-meshheading:1349728-Tetrodotoxin, pubmed-meshheading:1349728-Time Factors
pubmed:year
1992
pubmed:articleTitle
Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons.
pubmed:affiliation
Department of Molecular and Cellular Physiology, Beckman Center, Stanford University Medical Center, California 94305.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't