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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
22
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pubmed:dateCreated |
1992-6-3
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pubmed:abstractText |
Amyotrophic lateral sclerosis (ALS) is a chronic degenerative neurologic disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. Recent studies have suggested that the metabolism of glutamate, a potentially neurotoxic amino acid, is abnormal in patients with ALS. We hypothesized that the high-affinity glutamate transporter is the site of the defect.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
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pubmed:issn |
0028-4793
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
326
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1464-8
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1349424-Aged,
pubmed-meshheading:1349424-Alzheimer Disease,
pubmed-meshheading:1349424-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:1349424-Biological Transport,
pubmed-meshheading:1349424-Brain,
pubmed-meshheading:1349424-Female,
pubmed-meshheading:1349424-Glutamates,
pubmed-meshheading:1349424-Glutamic Acid,
pubmed-meshheading:1349424-Humans,
pubmed-meshheading:1349424-Huntington Disease,
pubmed-meshheading:1349424-Male,
pubmed-meshheading:1349424-Middle Aged,
pubmed-meshheading:1349424-Motor Cortex,
pubmed-meshheading:1349424-Phenylalanine,
pubmed-meshheading:1349424-Somatosensory Cortex,
pubmed-meshheading:1349424-Spinal Cord,
pubmed-meshheading:1349424-Synaptosomes,
pubmed-meshheading:1349424-Visual Cortex,
pubmed-meshheading:1349424-gamma-Aminobutyric Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis.
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pubmed:affiliation |
Department of Neurology, Johns Hopkins University, Baltimore, MD 21205.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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