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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-5-29
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pubmed:abstractText |
We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
745-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1349298-Animals,
pubmed-meshheading:1349298-CHO Cells,
pubmed-meshheading:1349298-Chromosome Mapping,
pubmed-meshheading:1349298-Chromosomes, Human, Pair 10,
pubmed-meshheading:1349298-Cricetinae,
pubmed-meshheading:1349298-DNA Repair,
pubmed-meshheading:1349298-Female,
pubmed-meshheading:1349298-Genetic Linkage,
pubmed-meshheading:1349298-Humans,
pubmed-meshheading:1349298-Hybrid Cells,
pubmed-meshheading:1349298-Male,
pubmed-meshheading:1349298-Mutation,
pubmed-meshheading:1349298-Pedigree,
pubmed-meshheading:1349298-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:1349298-Restriction Mapping,
pubmed-meshheading:1349298-Ultraviolet Rays
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pubmed:year |
1992
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pubmed:articleTitle |
Localization of the nucleotide excision repair gene ERCC6 to human chromosome 10q11-q21.
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pubmed:affiliation |
Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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