| pubmed-article:1348799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1348799 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:1348799 | lifeskim:mentions | umls-concept:C0085584 | lld:lifeskim |
| pubmed-article:1348799 | lifeskim:mentions | umls-concept:C0041228 | lld:lifeskim |
| pubmed-article:1348799 | lifeskim:mentions | umls-concept:C1302234 | lld:lifeskim |
| pubmed-article:1348799 | lifeskim:mentions | umls-concept:C0205332 | lld:lifeskim |
| pubmed-article:1348799 | pubmed:issue | 8799 | lld:pubmed |
| pubmed-article:1348799 | pubmed:dateCreated | 1992-5-19 | lld:pubmed |
| pubmed-article:1348799 | pubmed:abstractText | The treatment of late-stage African sleeping sickness in man is often complicated by a post-treatment reactive encephalopathy. The bases of this pathological reaction was investigated in a mouse model of African trypanosomiasis. Subcurative treatment with diminazene aceturate, which did not clear parasites from the central nervous system, resulted in a post-treatment meningoencephalitis similar to that seen in man. By contrast, a curative regimen of melaminylthioarsenite and 5-nitroimidazole, which cleared parasites from the central nervous system, did not cause any pathological reaction in the mice. This result indicates that subcurative treatment leads to the development of the post-treatment encephalopathy. Evidence that this may also be the case in man was provided by the detection of trypanosome DNA with the polymerase chain reaction in the brains of 9 patients who had died as the result of a post-treatment reaction. Our findings suggest that more aggressive treatment regimens, which ensure the elimination of trypanosomes from the central nervous system, may prevent post-treatment reactions in patients. | lld:pubmed |
| pubmed-article:1348799 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1348799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1348799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1348799 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1348799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1348799 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1348799 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:1348799 | pubmed:author | pubmed-author:MurrayMM | lld:pubmed |
| pubmed-article:1348799 | pubmed:author | pubmed-author:AdamsJ HJH | lld:pubmed |
| pubmed-article:1348799 | pubmed:author | pubmed-author:JenningsF WFW | lld:pubmed |
| pubmed-article:1348799 | pubmed:author | pubmed-author:KennedyP GPG | lld:pubmed |
| pubmed-article:1348799 | pubmed:author | pubmed-author:HunterC ACA | lld:pubmed |
| pubmed-article:1348799 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1348799 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:1348799 | pubmed:volume | 339 | lld:pubmed |
| pubmed-article:1348799 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1348799 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1348799 | pubmed:pagination | 956-8 | lld:pubmed |
| pubmed-article:1348799 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1348799 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1348799 | pubmed:articleTitle | Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis. | lld:pubmed |
| pubmed-article:1348799 | pubmed:affiliation | Department of Veterinary Medicine, University of Glasgow, UK. | lld:pubmed |
| pubmed-article:1348799 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1348799 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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