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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8799
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pubmed:dateCreated |
1992-5-19
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pubmed:abstractText |
The treatment of late-stage African sleeping sickness in man is often complicated by a post-treatment reactive encephalopathy. The bases of this pathological reaction was investigated in a mouse model of African trypanosomiasis. Subcurative treatment with diminazene aceturate, which did not clear parasites from the central nervous system, resulted in a post-treatment meningoencephalitis similar to that seen in man. By contrast, a curative regimen of melaminylthioarsenite and 5-nitroimidazole, which cleared parasites from the central nervous system, did not cause any pathological reaction in the mice. This result indicates that subcurative treatment leads to the development of the post-treatment encephalopathy. Evidence that this may also be the case in man was provided by the detection of trypanosome DNA with the polymerase chain reaction in the brains of 9 patients who had died as the result of a post-treatment reaction. Our findings suggest that more aggressive treatment regimens, which ensure the elimination of trypanosomes from the central nervous system, may prevent post-treatment reactions in patients.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
339
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
956-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1348799-Adolescent,
pubmed-meshheading:1348799-Adult,
pubmed-meshheading:1348799-Animals,
pubmed-meshheading:1348799-Arsenicals,
pubmed-meshheading:1348799-Brain,
pubmed-meshheading:1348799-Brain Diseases,
pubmed-meshheading:1348799-Child,
pubmed-meshheading:1348799-Child, Preschool,
pubmed-meshheading:1348799-Diminazene,
pubmed-meshheading:1348799-Female,
pubmed-meshheading:1348799-Humans,
pubmed-meshheading:1348799-Male,
pubmed-meshheading:1348799-Mice,
pubmed-meshheading:1348799-Nitroimidazoles,
pubmed-meshheading:1348799-Polymerase Chain Reaction,
pubmed-meshheading:1348799-Trypanocidal Agents,
pubmed-meshheading:1348799-Trypanosoma brucei brucei,
pubmed-meshheading:1348799-Trypanosomiasis, African
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pubmed:year |
1992
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pubmed:articleTitle |
Subcurative chemotherapy and fatal post-treatment reactive encephalopathies in African trypanosomiasis.
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pubmed:affiliation |
Department of Veterinary Medicine, University of Glasgow, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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