Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1992-4-30
|
| pubmed:abstractText |
To study the basis for immunological tolerance of peripheral tissue-specific antigens, a transgenic mouse line was established that expresses the influenza hemagglutinin (HA) on pancreatic islet beta cells (Ins-HA transgenic mice). When followed up to 14 months of age, Ins-HA transgenic mice did not develop spontaneous autoimmune disease. Upon immunization with HA-expressing viruses, high titers of HA-specific circulating antibody were detected; however, T cell responses by both the T helper and T cytolytic compartment were markedly reduced as compared with transgene-negative littermates, and no evidence could be found for islet infiltrates. Adoptive transfer of histocompatible lymphocytes from transgene-negative mice plus virus into irradiated Ins-HA hosts resulted in islet inflammation dominated by CD4+ T cells, indicating that the HA antigen was accessible to activated T cells. These results suggest that T cells can be rendered tolerant of antigens expressed outside the thymus.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1013-22
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1348026-Amino Acid Sequence,
pubmed-meshheading:1348026-Animals,
pubmed-meshheading:1348026-Antigens, CD8,
pubmed-meshheading:1348026-B-Lymphocytes,
pubmed-meshheading:1348026-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1348026-Cytotoxicity, Immunologic,
pubmed-meshheading:1348026-Hemagglutinins, Viral,
pubmed-meshheading:1348026-Immune Tolerance,
pubmed-meshheading:1348026-Immunization, Passive,
pubmed-meshheading:1348026-Influenza A virus,
pubmed-meshheading:1348026-Islets of Langerhans,
pubmed-meshheading:1348026-Lymphocyte Activation,
pubmed-meshheading:1348026-Major Histocompatibility Complex,
pubmed-meshheading:1348026-Mice,
pubmed-meshheading:1348026-Mice, Transgenic,
pubmed-meshheading:1348026-Molecular Sequence Data,
pubmed-meshheading:1348026-Peptides,
pubmed-meshheading:1348026-T-Lymphocyte Subsets,
pubmed-meshheading:1348026-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1348026-T-Lymphocytes, Helper-Inducer
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells.
|
| pubmed:affiliation |
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|