Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8788
|
| pubmed:dateCreated |
1992-2-25
|
| pubmed:abstractText |
Anti-GOR is an autoantibody found in hepatitis C virus (HCV) infection. We have studied the specificity of this antibody for HCV infection in various groups of autoimmune liver diseases. Anti-HCV was detected by a second generation HCV enzyme-linked immunosorbent assay in 14 of 29 patients with liver-kidney-microsomal (LKM-1) -antibody-positive autoimmune hepatitis type 2 and in all 6 control patients with HCV-RNA-positive chronic hepatitis C. Anti-HCV was not found in those with antinuclear-antibody-positive autoimmune hepatitis type 1 (10 patients), with soluble-liver-protein-antibody-positive autoimmune hepatitis type 3 (8), with primary biliary cirrhosis (9), with systemic lupus erythematosus (SLE) (10), or in healthy controls (13). Anti-GOR was detected in 11 of 14 patients with autoimmune hepatitis type 2 who were all positive for anti-HCV but only in 1 of 15 LKM-1 patients who were negative for anti-HCV. We did not find anti-GOR in any other group of autoimmune liver disease, SLE, or control sera, but this antibody was detected in 3 of 6 patients with chronic hepatitis C. Autoimmune hepatitis type 2 patients who were anti-GOR positive and anti-HCV positive were less likely to be female, were older (p less than 0.001), and had lower LKM-1 antibody titres (p less than 0.001), lower disease activity, and responded less effectively to immuno- suppression than did those who were anti-HCV negative/anti-GOR negative. The findings show that anti-GOR reflects HCV-specific autoimmunity. HCV seems to induce autoimmunity to both GOR (an HCV-specific autoepitope) and LKM-1 (an epitope that is also recognised by autoimmune hepatitis sera of a different cause). Anti-GOR and LKM-1 antibodies contribute to a better differentiation of chronic hepatitis, a finding that has therapeutic implications.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
339
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
267-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1346282-Adolescent,
pubmed-meshheading:1346282-Adult,
pubmed-meshheading:1346282-Age Factors,
pubmed-meshheading:1346282-Aged,
pubmed-meshheading:1346282-Autoantibodies,
pubmed-meshheading:1346282-Autoimmune Diseases,
pubmed-meshheading:1346282-Child,
pubmed-meshheading:1346282-Child, Preschool,
pubmed-meshheading:1346282-Female,
pubmed-meshheading:1346282-Hepacivirus,
pubmed-meshheading:1346282-Hepatitis, Chronic,
pubmed-meshheading:1346282-Hepatitis Antibodies,
pubmed-meshheading:1346282-Hepatitis C,
pubmed-meshheading:1346282-Humans,
pubmed-meshheading:1346282-Immunosuppression,
pubmed-meshheading:1346282-Male,
pubmed-meshheading:1346282-Microsomes, Liver,
pubmed-meshheading:1346282-Middle Aged,
pubmed-meshheading:1346282-Retrospective Studies,
pubmed-meshheading:1346282-Sex Factors
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Anti-GOR and hepatitis C virus in autoimmune liver diseases.
|
| pubmed:affiliation |
Abbott Laboratories, European Research and Development, Wiesbaden, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|