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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-10-14
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pubmed:abstractText |
Although growth-associated protein-43 (GAP-43) was initially considered to be neuron-specific, it has more recently been found in astrocytes, oligodendrocytes, Schwann cells, glial cell equivalents in embryonic Drosophila and other non-neuronal cells. Here I summarize evidence for the presence of GAP-43 in macroglial cells (i.e., astrocytes and oligodendrocytes) cultured from neonatal rat cortex and describe its developmental expression in a lineage-specific and cell-type-specific manner. These and other data suggest that GAP-43 is a multifunctional protein involved in the synthesis of membranes associated with the growth of various types of cellular processes, including those of macroglial cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1064-0517
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-43
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:1345684-Animals,
pubmed-meshheading:1345684-Astrocytes,
pubmed-meshheading:1345684-Cell Membrane,
pubmed-meshheading:1345684-Cells, Cultured,
pubmed-meshheading:1345684-Cerebral Cortex,
pubmed-meshheading:1345684-Drosophila,
pubmed-meshheading:1345684-GAP-43 Protein,
pubmed-meshheading:1345684-Gene Expression Regulation,
pubmed-meshheading:1345684-Mammals,
pubmed-meshheading:1345684-Membrane Glycoproteins,
pubmed-meshheading:1345684-Nerve Tissue Proteins,
pubmed-meshheading:1345684-Oligodendroglia,
pubmed-meshheading:1345684-Rats,
pubmed-meshheading:1345684-Schwann Cells
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pubmed:year |
1992
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pubmed:articleTitle |
GAP-43 expression in macroglial cells: potential functional significance.
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pubmed:affiliation |
National Institute of Mental Health, Rockville, MD 20857.
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pubmed:publicationType |
Journal Article,
Review
|