Linked Life Data

1343276

Source:http://linkedlifedata.com/resource/pubmed/id/1343276

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-3-8
pubmed:abstractText
The purpose of this study was to examine the effect of manidipine hydrochloride, a new calcium antagonist, on renal blood flow in healthy subjects, using the newly developed pulsed-Doppler flowmeter with colored flow imager and digital computer analyzer. Results in previous studies differed because the para-aminohippurate clearance method measures the average not real-time value. Sixteen healthy volunteers (n = 7, manidipine 20 mg; n = 9, placebo control) participated in the study. Before and 1 h after drug administration, pulsed-Doppler measurements were carried out by transabdominal approach with patients in the supine position. Manidipine hydrochloride increased renal blood flow significantly compared with placebo (13.8 +/- 4.7% vs. 6.1 +/- 5.6%; p < 0.05). There was a significant (p < 0.005) between group difference in the reduction in systolic blood pressure (-14.8 +/- 1.6 mmHg manidipine; -3.0 +/- 2.1 mmHg placebo). These data suggest that manidipine hydrochloride has a vasodilating effect on renal arterioles and a beneficial effect on the kidneys of hypertensive patients. Further, the pulsed-Doppler flowmeter may become a very useful tool for noninvasive measurement of renal blood flow.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0803-8023
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-5
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Acute effect of manidipine on renal blood flow measured by pulsed-Doppler flowmeter in normal subjects.
pubmed:affiliation
Department of Internal Medicine, Miyagi National Hospital, Japan.
pubmed:publicationType
Journal Article