Linked Life Data

1343000

Source:http://linkedlifedata.com/resource/pubmed/id/1343000

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-4
pubmed:dateCreated
1994-2-24
pubmed:abstractText
Antacids apart from neutralization of hydrochloric acid possess the gastro-protective properties. In this paper, performed in vivo and in vitro, we studied the effects of antacids (aluminium and magnesium hydroxides) on secretion of PGE2 and 6-keto-PGF1 alpha (a stable metabolite of PGI2) by the gastric mucosa and isolated gastric mucosal cells of rats. We studied protective effects of these drugs on the gastric mucosa and isolated cells as well. It was shown that antacids stimulate generation of PGE2 and PGI2 in the gastric mucosa and protect it against alcohol-induced damage. Indomethacin given prior to antacids in a dose (1 mg/kg) which did not cause any gastric mucosal changes but inhibited generation of both prostaglandins, abolished protective effects of antacids. In comparison with control, surface epithelial cells of the gastric mucosa isolated from the stomachs of rats which were treated with antacids earlier, secreted significantly more PGE2 and PGI2, and were less damaged after incubation with 8% alcohol. Indomethacin inhibited secretion of prostaglandins by isolated surface epithelial cells of the gastric mucosa and abolished protective effects of antacids on these cells. The study confirms both in vivo and in vitro the protective properties of antacids and shows that prostaglandins participate in their action.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0015-5616
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
37-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[In vivo and vitro study of prostaglandins E2 and I2 participation in protective function of antacids on gastric mucosa].
pubmed:affiliation
Kliniki Gastroenterologii, Akademii Medycznej im. M. Kopernika, Krakowie.
pubmed:publicationType
Journal Article, In Vitro, English Abstract