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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-11-6
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pubmed:abstractText |
Newly synthesized kainate derivatives, 4-(2-hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid (HFPA and 4-(2-methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid (MFPA), were potent inhibitors of [3H]kainate binding to the rat spinal cord synaptic membranes, comparable in their effectiveness to kainate and domoate, whereas acromelic acid A (ACRO-A) and B (ACRO-B) was much less effective than kainate. ACRO-A, MFPA and HFPA all inhibited [3H]AMPA binding. These novel kainate analogues provide new pharmacological tools for analyzing the mechanisms underlying activation of kainate/AMPA receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1341901-Amino Acids,
pubmed-meshheading:1341901-Animals,
pubmed-meshheading:1341901-Binding, Competitive,
pubmed-meshheading:1341901-Kainic Acid,
pubmed-meshheading:1341901-Male,
pubmed-meshheading:1341901-Neuromuscular Depolarizing Agents,
pubmed-meshheading:1341901-Rats,
pubmed-meshheading:1341901-Rats, Wistar,
pubmed-meshheading:1341901-Receptors, AMPA,
pubmed-meshheading:1341901-Receptors, Kainic Acid,
pubmed-meshheading:1341901-Receptors, Neurotransmitter,
pubmed-meshheading:1341901-Synaptic Membranes
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pubmed:year |
1992
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pubmed:articleTitle |
New, potent kainate derivatives: comparison of their affinity for [3H]kainate and [3H]AMPA binding sites.
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pubmed:affiliation |
National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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