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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6B
|
| pubmed:dateCreated |
1993-4-9
|
| pubmed:abstractText |
The present study was designed to determine the optimal therapeutic protocol for OK-432, a streptococcal preparation, and to clarify the kinetics of various immunological parameters following intracutaneous administration of OK-432 in 39 disease-free postoperative patients with early cancer. These patients were randomly divided into 4 groups according to the dose (1KE or 5KE) and the frequency of administration (one or 3 times every other day) of OK-432. NK activity 3-4 days after the first injection increased significantly in patients whose pretreatment baseline activity was below the lower level of normal values (60 LU) in all study groups (P < 0.05). The elevation of post-therapeutic NK activity lasted for 2 weeks in the group of patients given repeated injections. The serum content of cytotoxic activity against L-M cells increased significantly after the injection of OK-432 at doses of more than 5 KE doses (p < 0.05). These findings suggest that repeated injections of OK-432 over a period of a week have important immunotherapeutic results.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-7005
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1941-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1341892-Adult,
pubmed-meshheading:1341892-Aged,
pubmed-meshheading:1341892-Animals,
pubmed-meshheading:1341892-Cytotoxicity, Immunologic,
pubmed-meshheading:1341892-Dose-Response Relationship, Drug,
pubmed-meshheading:1341892-Drug Administration Schedule,
pubmed-meshheading:1341892-Female,
pubmed-meshheading:1341892-Humans,
pubmed-meshheading:1341892-Immunophenotyping,
pubmed-meshheading:1341892-Immunotherapy,
pubmed-meshheading:1341892-Killer Cells, Natural,
pubmed-meshheading:1341892-L Cells (Cell Line),
pubmed-meshheading:1341892-Lymphocytes,
pubmed-meshheading:1341892-Male,
pubmed-meshheading:1341892-Mice,
pubmed-meshheading:1341892-Middle Aged,
pubmed-meshheading:1341892-Neoplasm Staging,
pubmed-meshheading:1341892-Neoplasms,
pubmed-meshheading:1341892-Picibanil,
pubmed-meshheading:1341892-Tumor Cells, Cultured
|
| pubmed:articleTitle |
Effect of OK-432 on cytotoxic activity in cancer patients without tumor burden.
|
| pubmed:affiliation |
Department of Oto-Rhino-Laryngology, Fukui Medical School, Japan.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|