Linked Life Data

13416529

Source:http://linkedlifedata.com/resource/pubmed/id/13416529

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1957-12-1
pubmed:abstractText
Acetylcholine and factor I appear to be transmitter substances of excitatory and inhibitory regulatory nerve fibers supplying the sensory neurons of stretch receptor organs of the crayfish. Sudden application of a low concentration of acetylcholine causes the impulse frequency to jump to a peak value. But immediately the frequency falls again and gradually reaches a steady state which is not far above the previous frequency level. If the acetylcholine is now withdrawn there follows a silent period after which the frequency returns to its original level. The time course of these events is identical with that of adaptations to sudden increase or decrease of stretch. Factor I in sufficiently low concentrations causes an immediate fall in impulse frequency (silent period) which is followed by a return to a value near the previous frequency level. Withdrawal of factor I is followed by excitation and again return of the frequency to the rate measured before the application of factor I. The time course of these phenomena is identical with that of adaptations to sudden decrease and increase of stretch. It is suggested that adaptation may be a property not only of sensory neurons but of neurons in general and that even central neurons may be considered as receptor neurons inasmuch as they respond to chemically transmitted excitatory and inhibitory stimuli.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1295
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-45
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1957
pubmed:articleTitle
Chemical transmission and adaptation.
pubmed:publicationType
Journal Article