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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1993-9-16
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pubmed:abstractText |
At 28 months of age (old rats), male Fisher 344 rats which had been fed 40% of the ad libitum food intake since they were 6 months old, had a similar beta-adrenergic receptor density (Bmax) in their pineal gland as young, 3-month-old rats. In contrast, old rats which had been fed ad libitum for the same period had approximately 50% of the Bmax value compared to that of young rats. The beta-receptor density of cerebral cortical tissue and the beta-receptor affinity (Kd) of both the cortex and the pineal gland did not decline with age and was not affected by food restriction. The reduction in pineal beta-receptor density with age may be casually related to the concurrent age-associated decline in pineal production of melatonin.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1016-0922
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1339169-Aging,
pubmed-meshheading:1339169-Animals,
pubmed-meshheading:1339169-Cerebral Cortex,
pubmed-meshheading:1339169-Food Deprivation,
pubmed-meshheading:1339169-Male,
pubmed-meshheading:1339169-Pineal Gland,
pubmed-meshheading:1339169-Rats,
pubmed-meshheading:1339169-Rats, Inbred F344,
pubmed-meshheading:1339169-Receptors, Adrenergic, beta
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pubmed:articleTitle |
Age-associated reduction in pineal beta-adrenergic receptor density is prevented by life-long food restriction in rats.
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pubmed:affiliation |
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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