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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1993-5-6
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pubmed:abstractText |
The effect of the opioid agonist morphine and of the (-) and (+) stereoisomers of the antagonist naloxone were studied on the O2-generation from human granulocytes. Morphine or naloxone had no effect on basal or phorbol myristate acetate (PMA) stimulated O2-generation, while equimolar (-) naloxone and morphine concentrations (1 x 10-13 - 1 x 10-7 M) inhibited the stimulated O2-generation. The effect of (-) naloxone was stereospecific, suggesting the involvement of opioid receptors. The unmasking of non opioid effects of morphine could be responsible for the inhibition of O2-generation. It is suggested that the opioid control of oxidative metabolism in human granulocytes could involve multiple receptors mediating opposite effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0393-5264
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
445-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1338430-Adult,
pubmed-meshheading:1338430-Cells, Cultured,
pubmed-meshheading:1338430-Dose-Response Relationship, Drug,
pubmed-meshheading:1338430-Granulocytes,
pubmed-meshheading:1338430-Humans,
pubmed-meshheading:1338430-Male,
pubmed-meshheading:1338430-Morphine,
pubmed-meshheading:1338430-Naloxone,
pubmed-meshheading:1338430-Receptors, Opioid,
pubmed-meshheading:1338430-Superoxides,
pubmed-meshheading:1338430-Tetradecanoylphorbol Acetate
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pubmed:articleTitle |
In vitro effect of opioid agonist and antagonist on superoxide release by granulocytes.
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pubmed:affiliation |
Senior Institute of Health, Rome, Italy.
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pubmed:publicationType |
Journal Article
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