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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1993-4-23
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pubmed:abstractText |
Twenty patients with stage IIIA-IIIB non-small-cell lung cancer were treated with cisplatin, epirubicin and VP-16 (PEV) neoadjuvant chemotherapy (CDDP, 70 mg/m2, i.v., d 1; EDX, 60 mg/m2, i.v., d 1; VP-16, 100 mg/m2, i.v., d 1-2-3; every 3 weeks). A partial response was obtained in 11 cases (55%), stable disease in 3 cases (15%), and progressive disease in 6 cases (30%). After chemotherapy, 8 (40%) patients, all achieving a partial response, were elegible for surgery: 5 (25%) had a complete resection (4 IIIA and 1 IIIB) and 3 (15%) an incomplete resection. The treatment was well tolerated. These data show that PEV is an active regimen for neoadjuvant chemotherapy in NSCLC and recommend this therapeutic approach for stage IIIA patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0300-8916
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-9
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pubmed:dateRevised |
2008-12-12
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pubmed:meshHeading |
pubmed-meshheading:1338403-Adult,
pubmed-meshheading:1338403-Aged,
pubmed-meshheading:1338403-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1338403-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:1338403-Chemotherapy, Adjuvant,
pubmed-meshheading:1338403-Cisplatin,
pubmed-meshheading:1338403-Drug Administration Schedule,
pubmed-meshheading:1338403-Epirubicin,
pubmed-meshheading:1338403-Etoposide,
pubmed-meshheading:1338403-Female,
pubmed-meshheading:1338403-Humans,
pubmed-meshheading:1338403-Lung Neoplasms,
pubmed-meshheading:1338403-Male,
pubmed-meshheading:1338403-Middle Aged,
pubmed-meshheading:1338403-Neoplasm Staging,
pubmed-meshheading:1338403-Pilot Projects,
pubmed-meshheading:1338403-Treatment Outcome
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pubmed:year |
1992
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pubmed:articleTitle |
Neoadjuvant chemotherapy with cisplatin, epirubicin and VP-16 for stage IIIA-IIIB non-small-cell lung cancer: a pilot study.
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pubmed:affiliation |
Cattedra di Oncologia Medica, II Facoltà di Medicina, Università di Napoli, Italy.
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pubmed:publicationType |
Journal Article
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