Linked Life Data

1337850

Source:http://linkedlifedata.com/resource/pubmed/id/1337850

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1993-3-29
pubmed:abstractText
The de novo megakaryocytic leukemia fulfilling the FAB criteria is still an uncommonly recognized variant of acute leukemia. Many studies have shown that the megakaryocytic leukemic events may occur at a pluripotent stem cell level and clinical observations reveal that the megakaryocytic leukemias are diverse entities. The immunophenotyping using monoclonal antibodies against platelet specific surface antigens and the ultrastructural detection of platelet peroxidase reaction do not provide sufficiently useful information to determine whether a megakaryocytic leukemia is chronic, acute, therapy-responsive or therapy-unresponsive. More sophisticated techniques are required to further characterize megakaryocytic leukemic cells. In this review, we emphasize that megakaryocytic leukemic cells can be categorized into two groups; one with the PF4 mRNA, and the other without it, and that the expression of PF4 mRNA in the blasts could be a useful marker for the identification of mature megakaryoblasts. It seems that the patients with blasts expressing PF4 mRNA will have a longer survival and a better response to chemotherapy than those without PF4. We further discuss the fact that the detection of mRNAs of the IL-6 receptor, PDGF A- and B-chains, and TGF beta 1 in megakaryocytic leukemic cells will be useful to clarify the mechanisms involved in the proliferation of megakaryocytic leukemic cells and fibroblasts in the bone marrow. Furthermore, we reviewed data showing that megakaryocytic erythroid, and mast cell lineages share the nuclear transcription factor known as GF-1 (NF-E1 or Erf-1). We suggest that characterization of megakaryocytic leukemia should be performed using monoclonal antibodies against erythroid, megakaryocytic and mast cell lineages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-36
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:1337850-Base Sequence, pubmed-meshheading:1337850-Cell Differentiation, pubmed-meshheading:1337850-Cytoplasmic Granules, pubmed-meshheading:1337850-Gene Expression Regulation, Leukemic, pubmed-meshheading:1337850-Growth Substances, pubmed-meshheading:1337850-Humans, pubmed-meshheading:1337850-Leukemia, Megakaryoblastic, Acute, pubmed-meshheading:1337850-Megakaryocytes, pubmed-meshheading:1337850-Molecular Sequence Data, pubmed-meshheading:1337850-Neoplasm Proteins, pubmed-meshheading:1337850-Neoplastic Stem Cells, pubmed-meshheading:1337850-Peroxidase, pubmed-meshheading:1337850-Platelet Factor 4, pubmed-meshheading:1337850-Platelet Membrane Glycoproteins, pubmed-meshheading:1337850-Prevalence, pubmed-meshheading:1337850-Transcription Factors, pubmed-meshheading:1337850-Tumor Markers, Biological
pubmed:year
1992
pubmed:articleTitle
Megakaryocytic leukemia and platelet factor 4.
pubmed:affiliation
Blood Transfusion Service, Kobe University Hospital, Japan.
pubmed:publicationType
Journal Article, Review