Linked Life Data

1337192

Source:http://linkedlifedata.com/resource/pubmed/id/1337192

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-3-2
pubmed:abstractText
The effects of the volatile anesthetic enflurane on voltage-gated ionic currents of bovine adrenal chromaffin cells were studied using the patch clamp technique. Bath application of 3.5% (1.7 mM) enflurane decreased the outward Ca(2+)-dependent K+ current (IK(Ca)) 'hump' by 88 +/- 6% (mean +/- S.E.M., n = 5 cells) and the peak inward Ca2+ current by 60 +/- 3% (n = 5), whereas the Ca(2+)-independent K+ current fell by only 34 +/- 3% (n = 5) and peak inward Na+ current was unchanged. Exposure of excised patch 'BK' Ca(2+)-dependent K+ channels to 3.5% enflurane revealed that the anesthetic directly suppressed the channel probability of opening by 68 +/- 10% (n = 4) with no effect on open state conductance. The differential sensitivity of depolarizing and hyperpolarizing current pathways may contribute to the biphasic response, excitation and depression, observed in certain neuronal systems in response to this inhalational anesthetic.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-51
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Effects of enflurane on the voltage-gated membrane currents of bovine adrenal chromaffin cells.
pubmed:affiliation
Department of Anesthesiology, University of Virginia Health Sciences Center, Charlottesville 22908.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.