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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1993-2-23
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pubmed:abstractText |
The distribution of the alpha 6 subunit of the GABAA receptor has been established in rat cerebellum and compared to the distribution of the alpha 1 (cat) and the beta 2/3 (rat, cat) subunits, using immunocytochemistry. The synapses established by Golgi cell terminals on the dendrites of granule cells were immunoreactive for the alpha 6, alpha 1 and beta 2/3 subunits in virtually all glomeruli, indicating that two variants (alpha 1 and alpha 6) of the same subunit are co-localized at the same synapses. The somatic membranes of the granule cells, which receive no synapses, were immunopositive for the alpha 1 and beta 2/3 subunits, but not for the alpha 6 subunit. Thus, the alpha 1 and the beta 2/3 subunits are located at both synaptic and extrasynaptic sites, but the alpha 6 subunit is detectable only at synaptic sites.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0306-4522
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
739-48
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1336825-Animals,
pubmed-meshheading:1336825-Cats,
pubmed-meshheading:1336825-Cerebellar Cortex,
pubmed-meshheading:1336825-In Situ Hybridization,
pubmed-meshheading:1336825-Microscopy, Electron,
pubmed-meshheading:1336825-Rats,
pubmed-meshheading:1336825-Receptors, GABA-A,
pubmed-meshheading:1336825-Subcellular Fractions,
pubmed-meshheading:1336825-Synapses
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pubmed:year |
1992
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pubmed:articleTitle |
Differential subcellular distribution of the alpha 6 subunit versus the alpha 1 and beta 2/3 subunits of the GABAA/benzodiazepine receptor complex in granule cells of the cerebellar cortex.
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pubmed:affiliation |
Medical Research Council, Oxford University, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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