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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
1993-2-5
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pubmed:abstractText |
Dilute hydrogen bromide in trifluoroacetic acid containing pentamethylbenzene and thioanisole was used in the cleavage and deprotection of peptides on MBHA-resin. Particular attention was paid to potential applicability of the method to kilogram scale synthesis of thymosin alpha 1. In the HPLC purification of the peptides, acetonitrile was replaced by relatively nontoxic isopropanol. The change should be economically and environmentally very attractive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-methylbenzhydrylamine resin,
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Acetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzhydryl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrobromic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Isobutyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Pentanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Resins, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/Thymosin,
http://linkedlifedata.com/resource/pubmed/chemical/Trifluoroacetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin,
http://linkedlifedata.com/resource/pubmed/chemical/isobutyric acid,
http://linkedlifedata.com/resource/pubmed/chemical/isovaleric acid,
http://linkedlifedata.com/resource/pubmed/chemical/pivalic acid,
http://linkedlifedata.com/resource/pubmed/chemical/thymalfasin
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pubmed:status |
MEDLINE
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pubmed:issn |
0367-8377
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
344-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1335998-Acetic Acid,
pubmed-meshheading:1335998-Acetic Acids,
pubmed-meshheading:1335998-Acids,
pubmed-meshheading:1335998-Amino Acid Sequence,
pubmed-meshheading:1335998-Benzhydryl Compounds,
pubmed-meshheading:1335998-Butyric Acids,
pubmed-meshheading:1335998-Chromatography, High Pressure Liquid,
pubmed-meshheading:1335998-Hydrobromic Acid,
pubmed-meshheading:1335998-Isobutyric Acids,
pubmed-meshheading:1335998-Molecular Sequence Data,
pubmed-meshheading:1335998-Pentanoic Acids,
pubmed-meshheading:1335998-Peptide Mapping,
pubmed-meshheading:1335998-Peptides,
pubmed-meshheading:1335998-Resins, Synthetic,
pubmed-meshheading:1335998-Thymosin,
pubmed-meshheading:1335998-Trifluoroacetic Acid,
pubmed-meshheading:1335998-Trypsin
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pubmed:articleTitle |
Cleavage and deprotection of peptides on MBHA-resin with hydrogen bromide.
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pubmed:affiliation |
Alpha 1 Biomedicals, Inc., Foster City, CA.
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pubmed:publicationType |
Journal Article
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