Linked Life Data

1334721

Source:http://linkedlifedata.com/resource/pubmed/id/1334721

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-1-27
pubmed:abstractText
Platelet-activating factor (PAF) has been implicated as a cause of cardiopulmonary disturbances in certain diseases. In the present study, concentrations of PAF in hearts, lungs, whole blood, and other organs of control and Pichinde virus-infected guinea pigs on post-inoculation days (PID) 10 and 14 were measured by radioimmunoassay. Results were further confirmed by bioassay after separation and purification with thin-layer chromatography. PAF concentration in the hearts and lungs of virus-infected animals increased significantly on PID 10 and 14, as compared with control levels. PAF level in the blood of infected guinea pigs also significantly increased on PID 14. There was little change of PAF levels in liver and kidney after viral inoculation. Increased PAF concentrations in both hearts and lungs of infected strain 13 guinea pigs suggest that this lipid mediator may play an important role in the development of cardiopulmonary disturbances.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0921-8319
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
261-70
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Increased platelet-activating factor (PAF) concentrations in hearts and lungs of Pichinde virus-infected guinea pigs.
pubmed:affiliation
Department of Clinical and Experimental Physiology, United States Army Medical Research Institute of Infectious Disease, Fort Detrick, Frederick, MD 21702-5011.
pubmed:publicationType
Journal Article