|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1977-3-31
|
|
pubmed:abstractText |
Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists-metiamide and cimetidine-behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0028-1298
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
296
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
139-42
|
|
pubmed:dateRevised |
2009-10-27
|
|
pubmed:meshHeading |
pubmed-meshheading:13317-Animals,
pubmed-meshheading:13317-Female,
pubmed-meshheading:13317-Gastric Juice,
pubmed-meshheading:13317-Gastric Mucosa,
pubmed-meshheading:13317-Guanidines,
pubmed-meshheading:13317-Guinea Pigs,
pubmed-meshheading:13317-Histamine,
pubmed-meshheading:13317-Histamine H2 Antagonists,
pubmed-meshheading:13317-Imidazoles,
pubmed-meshheading:13317-Metiamide,
pubmed-meshheading:13317-Models, Biological,
pubmed-meshheading:13317-Receptors, Drug,
pubmed-meshheading:13317-Thiourea
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
