Linked Life Data

1331678

Source:http://linkedlifedata.com/resource/pubmed/id/1331678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1992-12-14
pubmed:abstractText
ProELH is the prohormone to the bag cell egg-laying peptide of Aplysia. In addition to containing the structure of the hormone (ELH) itself, proELH also contains several other secreted peptides: AP (acidic peptide) and alpha-, beta-, and gamma-bag cell peptides (BCPs). The BCPs, ranging in length from 5 to 9 amino acids, are structurally similar in that they all contain the sequence Arg-Leu-Arg-Phe. An additional peptide from the atrial gland, Atrial A, also contains this sequence. The BCPs previously have been reported to have direct feedback (autocrine) effects on the bag cells, including electrophysiological excitation and inhibition. Moreover, some of these effects are temperature-dependent. The autocrine functions of these peptides were explored here by investigating their effects on bag cell cAMP levels. In addition, we monitored the effects of Atrial A, as well as ELH and AP, which are proELH products that do not have sequence homology with the BCPs. While ELH and AP have no effect on bag cell cAMP levels, the other peptides fall into two functional classes. alpha- and gamma-BCP produce an elevation of cAMP levels at 20 degrees and a depression at 15 degrees C. The elevation in cAMP is sensitive to low Ca2+/high Mg2+. beta-BCP and Atrial A elevate cAMP levels independently of temperature, and are insensitive to low Ca2+/high Mg2+. Our results suggest that there may be multiple bag cell receptors for these peptides with the Arg-Leu-Arg-Phe sequence representing a receptor-recognition motif.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0169-328X
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
216-20
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
ProELH-related peptides: influence on bag cell cAMP levels.
pubmed:affiliation
Northwestern University, Department of Cell, Molecular and Structural Biology, Chicago, IL 60611.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.