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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-12-2
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pubmed:databankReference |
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pubmed:abstractText |
A beta subunit of the neuronal nicotinic receptor, sharing 88% homology with the rat beta 4 subunit, has been cloned from a human neuroblastoma cell line. The gene encoding the human beta 4 subunit is expressed in association with the alpha 3 gene in neuroblastoma and small-cell lung carcinoma cell lines. Patch-clamp experiments and radioligand binding assays confirm that these neuroendocrine tumor cell lines express functional neuronal nicotinic receptors. We suggest that these receptors might play a crucial role in the control of neurotransmitter and hormone secretion from neurosecretory human tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
312
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1330682-Acetylcholine,
pubmed-meshheading:1330682-Amino Acid Sequence,
pubmed-meshheading:1330682-Animals,
pubmed-meshheading:1330682-Base Sequence,
pubmed-meshheading:1330682-Carbachol,
pubmed-meshheading:1330682-Carcinoma, Small Cell,
pubmed-meshheading:1330682-Humans,
pubmed-meshheading:1330682-Lung Neoplasms,
pubmed-meshheading:1330682-Macromolecular Substances,
pubmed-meshheading:1330682-Membrane Potentials,
pubmed-meshheading:1330682-Molecular Sequence Data,
pubmed-meshheading:1330682-Neuroblastoma,
pubmed-meshheading:1330682-Neurons,
pubmed-meshheading:1330682-Oligodeoxyribonucleotides,
pubmed-meshheading:1330682-Onium Compounds,
pubmed-meshheading:1330682-Polymerase Chain Reaction,
pubmed-meshheading:1330682-Rats,
pubmed-meshheading:1330682-Receptors, Nicotinic,
pubmed-meshheading:1330682-Sequence Homology, Amino Acid,
pubmed-meshheading:1330682-Trityl Compounds,
pubmed-meshheading:1330682-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines.
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pubmed:affiliation |
Department of Medical Pharmacology, University of Milan, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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