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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1992-12-14
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pubmed:abstractText |
The relative contribution of the direct and indirect pathways to liver glycogen formation was assessed in humans by using a combined tracer-hepatic vein catheterization technique. An oral glucose load (75 g) labelled with 1-14C-glucose was administered to five subjects (control group) and 4.5 h later hepatic glycogen was flushed with glucagon and analysed to determine the randomization of 14C. The specific activity (SA) of the glycogen derived glucose (1-14C-glucose SA+recycled 14C-glucose SA) was 61 +/- 7% of the mean blood glucose SA of the interval 0-180 min after the oral glucose load. The relative values due to 1-14C-glucose and recycled 14C-glucose were 33 +/- 7 and 28 +/- 3%, respectively. The data indicate that the indirect pathway of glycogen formation is not only active in humans but contributes substantially (at least 50%) to liver glycogen formation. In order to investigate whether the basal adrenergic tone plays a role in the maintenance of the indirect pathway, the same protocol was also performed in a second group of subjects (n = 5) who received propranolol before the oral glucose load (propranolol group). The SA of the glycogen-derived glucose was considerably smaller than that of the control group (18 +/- 5 vs. 61 +/- 7%, P < 0.001), suggesting lesser glycogen formation. However, the ratio of 1-14C to recycled-14C in the glucose molecule was similar in the control (1.3 +/- 0.4) and propranolol group (1.9 +/- 1.2). We conclude that the basal adrenergic tone does not play any role in the operation of the indirect pathway of liver glycogen synthesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Liver Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0144-5979
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
641-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1330417-Adult,
pubmed-meshheading:1330417-Aged,
pubmed-meshheading:1330417-Blood Glucose,
pubmed-meshheading:1330417-Carbon Radioisotopes,
pubmed-meshheading:1330417-Female,
pubmed-meshheading:1330417-Glucagon,
pubmed-meshheading:1330417-Humans,
pubmed-meshheading:1330417-Insulin,
pubmed-meshheading:1330417-Liver Circulation,
pubmed-meshheading:1330417-Liver Glycogen,
pubmed-meshheading:1330417-Male,
pubmed-meshheading:1330417-Middle Aged,
pubmed-meshheading:1330417-Propranolol,
pubmed-meshheading:1330417-Receptors, Adrenergic, beta
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pubmed:year |
1992
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pubmed:articleTitle |
Indirect pathway of liver glycogen synthesis in humans is predominant and independent of beta-adrenergic mechanisms.
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pubmed:affiliation |
Department of Internal Medicine, Federico II University Second School of Medicine, Napoli, Italy.
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pubmed:publicationType |
Journal Article
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