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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-12-9
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pubmed:abstractText |
The domain model of Ca2+ inactivation of Ca2+ channels, which has been used to explain rapid inactivation of whole cell Ca2+ currents in pancreatic beta cells, is applied to single-time and conditional open probability measurements on guinea pig ventricular myocyte Ca2+ channels. These two measurements greatly constrain the choice of kinetic constants in the model. Calculations with the model provide a simple quantitative explanation of recent experimental results, including a slow increase in the inactivation rate.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1330028-Animals,
pubmed-meshheading:1330028-Biophysical Phenomena,
pubmed-meshheading:1330028-Biophysics,
pubmed-meshheading:1330028-Calcium,
pubmed-meshheading:1330028-Calcium Channels,
pubmed-meshheading:1330028-Islets of Langerhans,
pubmed-meshheading:1330028-Kinetics,
pubmed-meshheading:1330028-Models, Biological,
pubmed-meshheading:1330028-Probability,
pubmed-meshheading:1330028-Stochastic Processes
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pubmed:year |
1992
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pubmed:articleTitle |
Conditional probability analysis for a domain model of Ca(2+)-inactivation of Ca2+ channels.
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pubmed:affiliation |
Institute of Theoretical Dynamics, University of California, Davis 95616.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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