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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1992-12-21
|
| pubmed:abstractText |
61 squamous cell cancers (27 laryngeal, 12 hypopharyngeal, 14 tonsillary, 8 tongue) with different keratinization and grading and seven lymph node metastases of HPV 16/18 positive carcinomas were analysed for the presence of HPV-DNA by in situ hybridisation. 65.5% of them were found to be positive. Twelve laryngeal carcinomas (44%), five tonsillary tumours (35.7%), eight tumours of the hypopharynx (66.6%) and three tongue carcinomas (37.5%) were shown to contain HPV 16/18 DNA. The detection rates of HPV 6/11 were lower. 44 of the analysed tumours (72.1%) had a grading G2. 29 of these tumours (65.9%) were HPV positive. Only eight of the patients were no heavy smokers or alcoholic drinkers. One of the lymph node metastases was positive for HPV 16/18. The results indicate that HPV may be involved in the pathogenesis of squamous cell carcinomas of head and neck tumours.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0935-8943
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
500-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1329798-Biopsy,
pubmed-meshheading:1329798-Carcinoma, Squamous Cell,
pubmed-meshheading:1329798-Cell Transformation, Neoplastic,
pubmed-meshheading:1329798-Cocarcinogenesis,
pubmed-meshheading:1329798-DNA, Viral,
pubmed-meshheading:1329798-DNA Probes, HPV,
pubmed-meshheading:1329798-Female,
pubmed-meshheading:1329798-Humans,
pubmed-meshheading:1329798-Hypopharyngeal Neoplasms,
pubmed-meshheading:1329798-Laryngeal Neoplasms,
pubmed-meshheading:1329798-Lymph Nodes,
pubmed-meshheading:1329798-Lymphatic Metastasis,
pubmed-meshheading:1329798-Male,
pubmed-meshheading:1329798-Middle Aged,
pubmed-meshheading:1329798-Otorhinolaryngologic Neoplasms,
pubmed-meshheading:1329798-Papillomaviridae,
pubmed-meshheading:1329798-Tongue Neoplasms,
pubmed-meshheading:1329798-Tonsillar Neoplasms,
pubmed-meshheading:1329798-Tumor Virus Infections
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
[Type 6/11 and 16/18 squamous epithelial cancers of the upper respiratory tract and digestive system. An in situ hybridization study].
|
| pubmed:affiliation |
HNO-Abteilung, Marienkrankenhauses Hamburg.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|