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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3 Pt 2
|
| pubmed:dateCreated |
1992-10-29
|
| pubmed:abstractText |
Coronary stenosis was induced in rats to determine whether chronic coronary artery constriction resulted in impairment of cardiac pump performance, alterations in alpha 1-adrenoreceptor signal transduction, and inadequate myocardial hypertrophy, and these parameters were examined 6 mo later. A 50% reduction in coronary diameter was associated with an elevation in left ventricular end-diastolic pressure, whereas left ventricular peak systolic pressure, rate of pressure rise and decay were reduced. The hypertrophic response was modest, since statistically significant increases of 11% and 23% in left and right ventricular weights were measured. Radioligand binding documented an 18% and a 38% statistically significant reduction in alpha 1-adrenoreceptor density of the left and right myocardium, respectively. ADP ribosylation of the 41-kDa substrate by pertussis toxin showed a 16% significant decrease of this parameter in the left myocardium. Moreover, a 29% decrease in norepinephrine stimulated phosphoinositol turnover was seen in myocytes, and this change was statistically significant. The depressed generation of intracellular second messengers linked to the alpha 1-adrenoreceptors was found in conjunction with a 19% significant reduction in myocardial norepinephrine content. In conclusion, the long-term effects of coronary stenosis involve impaired transduction of adrenergic signals, which, in combination with constraints on myocardial growth, may participate in the onset of ventricular dysfunction in this model.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotide Probes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-9513
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
263
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
H929-38
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1329538-Actins,
pubmed-meshheading:1329538-Adenosine Diphosphate Ribose,
pubmed-meshheading:1329538-Animals,
pubmed-meshheading:1329538-Base Sequence,
pubmed-meshheading:1329538-Chronic Disease,
pubmed-meshheading:1329538-Constriction, Pathologic,
pubmed-meshheading:1329538-Coronary Disease,
pubmed-meshheading:1329538-GTP-Binding Proteins,
pubmed-meshheading:1329538-Heart,
pubmed-meshheading:1329538-Inositol Phosphates,
pubmed-meshheading:1329538-Male,
pubmed-meshheading:1329538-Molecular Sequence Data,
pubmed-meshheading:1329538-Myocardial Ischemia,
pubmed-meshheading:1329538-Norepinephrine,
pubmed-meshheading:1329538-Oligonucleotide Probes,
pubmed-meshheading:1329538-Rats,
pubmed-meshheading:1329538-Rats, Sprague-Dawley,
pubmed-meshheading:1329538-Receptors, Adrenergic, alpha,
pubmed-meshheading:1329538-Signal Transduction
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Chronic coronary arterial stenosis impairs alpha 1-adrenoreceptor signaling and cardiac performance in rats.
|
| pubmed:affiliation |
Department of Medicine, New York Medical College, Valhalla 10595.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|