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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-11-23
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pubmed:abstractText |
The toxicity of a new antiviral agent, 6-methoxypurine arabinoside (ara-M), as a selective and potent inhibitor against varicella-zoster virus, was investigated after intravitreal injection in rabbit eyes. Intravitreal doses of ara-M ranging from 20 micrograms to 400 micrograms produced no retinal toxicity, as assessed by electroretinography and light and transmission electron microscopy. These data suggest a potential role for intravitreal ara-M in the antiviral treatment of varicella-zoster viral retinitis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0275-004X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1329170-Animals,
pubmed-meshheading:1329170-Antiviral Agents,
pubmed-meshheading:1329170-Arabinonucleosides,
pubmed-meshheading:1329170-Electroretinography,
pubmed-meshheading:1329170-Eye Infections, Viral,
pubmed-meshheading:1329170-Herpesvirus 3, Human,
pubmed-meshheading:1329170-Injections,
pubmed-meshheading:1329170-Photoreceptor Cells,
pubmed-meshheading:1329170-Rabbits,
pubmed-meshheading:1329170-Retina,
pubmed-meshheading:1329170-Retinitis,
pubmed-meshheading:1329170-Vitreous Body
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pubmed:year |
1992
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pubmed:articleTitle |
Retinal toxicity of 6-methoxypurine arabinoside (ara-M). A new selective and potent inhibitor of varicella-zoster virus.
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pubmed:affiliation |
Louisiana State University Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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