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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1992-11-17
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pubmed:abstractText |
Relying on quantitative measurements of Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the endoplasmic reticulum, we construct a simplified kinetic model to describe the properties of this channel. Selecting rate constants to fit key kinetic and equilibrium data, we find that the model reproduces a variety of in vivo and in vitro experiments. In combination with Ca(2+)-ATPase activity for Ca2+ uptake into the endoplasmic reticulum, the model leads to cytoplasmic oscillations in Ca2+ concentration at fixed IP3 concentration and only a single pool of releasable Ca2+, the endoplasmic reticulum. Incorporation of a positive-feedback mechanism of Ca2+ on IP3 production by phospholipase C enriches the properties of the oscillations and leads to oscillations in Ca2+ concentration accompanied by oscillations in IP3 concentration. We discuss the possible significance of these results for the interpretation of experiments.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1324019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1647879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1648178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1691015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1719158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1719424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1846707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1867714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1946414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-1986413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2011747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2017683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2059999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2177621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2296584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2498663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2554143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2784673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-2829842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329108-3304139
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9895-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1329108-Calcium,
pubmed-meshheading:1329108-Calcium Channels,
pubmed-meshheading:1329108-Feedback,
pubmed-meshheading:1329108-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:1329108-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:1329108-Ion Channel Gating,
pubmed-meshheading:1329108-Kinetics,
pubmed-meshheading:1329108-Models, Theoretical,
pubmed-meshheading:1329108-Periodicity,
pubmed-meshheading:1329108-Receptors, Cell Surface,
pubmed-meshheading:1329108-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:1329108-Second Messenger Systems,
pubmed-meshheading:1329108-Signal Transduction
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pubmed:year |
1992
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pubmed:articleTitle |
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
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pubmed:affiliation |
Institute of Theoretical Dynamics, University of California, Davis 95616.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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