Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
1992-11-17
pubmed:abstractText
Muscarinic receptors mediating suppression of Ca2+ current and of M-type K+ current in rat superior cervical ganglion neurons were subclassified pharmacologically by using the muscarinic receptor antagonists pirenzepine and himbacine. Our voltage clamp experiments previously distinguished fast and slow intracellular signaling pathways coupling muscarinic receptors to calcium channels. We now establish that the fast, pertussis toxin-sensitive suppression of Ca2+ current is mediated primarily by muscarinic receptors of the M4 subtype, whereas the slow, bis(2-aminophenoxy)-ethane-N,N,N',N'-tetraacetate (BAPTA)-sensitive suppression of Ca2+ current is mediated primarily by muscarinic receptors of the M1 subtype. Both actions on Ca2+ current are blocked by guanosine 5'-[beta-thio]diphosphate. Muscarinic suppression of M current is slow, BAPTA-sensitive, and mediated by receptors of the M1 subtype. Hence the two muscarinic pathways use different receptors and different guanine nucleotide binding proteins to produce different actions on channels.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1000135, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1316767, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1346090, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-13651579, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1647174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1657056, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1678423, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1690565, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1717018, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1786516, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1846449, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1847065, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1905146, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1921982, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1980742, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-1994002, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2024288, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2188581, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2250662, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2438697, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2447647, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2465631, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2560643, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2689633, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2704370, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2819334, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2841607, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2843772, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-2844551, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3037705, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3110621, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3139847, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3272174, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3402600, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3762692, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3792556, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-3951563, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-6267618, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-6270629, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-6965523, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-7279296, http://linkedlifedata.com/resource/pubmed/commentcorrection/1329101-7350532
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9544-8
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Characterization of muscarinic receptor subtypes inhibiting Ca2+ current and M current in rat sympathetic neurons.
pubmed:affiliation
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't