Linked Life Data

1328562

Source:http://linkedlifedata.com/resource/pubmed/id/1328562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-11-18
pubmed:abstractText
Noradrenergic modulation of the glutamatergic-GABAergic synapses between mitral/tufted (M/T) and granule cells has been implicated in some forms of olfactory learning (Brennan et al., 1990). Norepinephrine (NE) has been shown to disinhibit mitral cells (Jahr and Nicoll, 1982), but its site of action is not well defined. The effects of NE on synaptic transmission between monosynaptically coupled pairs of mitral and granule cells have been examined using primary culture and whole-cell recording techniques. Intracellular stimulation of M/T cells evoked dual-component EPSPs in granule cells consisting of both NMDA and AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) receptor-mediated mechanisms. The EPSPs were reversibly inhibited by approximately 50% during application of 30 microM NE. NE had no effect, however, on the membrane current evoked by exogenous application of glutamate, indicating a presynaptic site of action. The effect of NE on EPSPs was mimicked by the alpha-adrenergic agonist clonidine but not by the beta-adrenergic agonist isoproterenol. NE had no significant effect on either accommodation or macroscopic currents in either M/T or granule cells. NE also inhibited spontaneous GABAergic IPSPs recorded in M/T cells, by a presynaptic alpha-adrenergic-mediated mechanism. These results support previous results suggesting a disinhibitory role for NE in the olfactory bulb. This action, however, is at least in part mediated by a reduction in mitral cell-mediated granule cell excitation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3985-91
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures.
pubmed:affiliation
Section of Neurobiology, Yale University Medical School, New Haven, Connecticut 06510.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.