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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-11-2
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pubmed:databankReference |
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pubmed:abstractText |
Subunit VIIa of mammalian cytochrome c oxidase (COX; EC 1.9.3.1) exists in at least two isoforms, one present in all tissue types ('liver' isoform; COX VIIa-L) and the other specific for cardiac and skeletal muscle (COX VIIa-M). We have isolated a full-length cDNA encoding human COX VIIa-M. The deduced polypeptide represents the human ortholog of COX VIIa-M, as it shares 78% identity with bovine COX VIIa-M, but only 63% identity with human COX VIIa-L. Northern-blot analysis of primate tissues demonstrated that COXVIIa-M mRNA is present only in muscle tissues; in contrast, the COXVIIa-L mRNA is present in both muscle and nonmuscle tissues. Southern-blot hybridization of human-rodent cell hybrid genomic DNA indicates that the COXVIIa-M gene maps to a single locus on chromosome 19, designated COX7AM. In contrast, COXVIIa-L cDNA probes hybridized to fragments from two COX7AL loci, on chromosomes 4 and 14.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
119
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pubmed:geneSymbol |
COXVIIa,
COXVIIa -M
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-305
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1327965-Amino Acid Sequence,
pubmed-meshheading:1327965-Animals,
pubmed-meshheading:1327965-Base Sequence,
pubmed-meshheading:1327965-Blotting, Northern,
pubmed-meshheading:1327965-Chromosome Mapping,
pubmed-meshheading:1327965-Chromosomes, Human, Pair 19,
pubmed-meshheading:1327965-Cytochrome-c Oxidase Deficiency,
pubmed-meshheading:1327965-DNA,
pubmed-meshheading:1327965-Electron Transport Complex IV,
pubmed-meshheading:1327965-Humans,
pubmed-meshheading:1327965-Isoenzymes,
pubmed-meshheading:1327965-Molecular Sequence Data,
pubmed-meshheading:1327965-Muscles,
pubmed-meshheading:1327965-Organ Specificity,
pubmed-meshheading:1327965-Sequence Homology, Amino Acid,
pubmed-meshheading:1327965-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1327965-Transcription, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase.
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pubmed:affiliation |
H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Disorders, Columbia University College of Physicians and Surgeons, New York, NY 10032.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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