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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1992-11-20
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pubmed:abstractText |
1. In the present study, we investigated the relationship between relaxation and guanosine 3':5'-cyclic monophosphate (cyclic GMP) formation induced by KRN2391, compared with those induced by nicorandil and nitroglycerin, in the coronary artery of the pig. 2. KRN2391 (10(-8)-3 X 10(-5) M), nicorandil (10(-8)-3 X 10(-4) M) and nitroglycerin (10(-9)-10(-5) M) antagonized the contraction caused by 25 mM KCl in a concentration-dependent manner. 3. The concentration-relaxation curves for KRN2391, nicorandil and nitroglycerin shifted rightward in the presence of methylene blue (10(-5) M). 4. KRN2391 (10(-6) M), nicorandil (10(-4) M) and nitroglycerin (10(-6) M) induced an increased in cyclic GMP. 5. The magnitude of the shift of the concentration-relaxation curve caused by methylene blue and the increase in cyclic GMP with KRN2391 were lower than those with nicorandil and nitroglycerin. 6. The adenosine 3':5'-cyclic monophosphate (cyclic AMP) level was not increased by KRN2391 even at a concentration that produced full relaxation. 7. The present results suggest that KRN2391-induced relaxation in the coronary artery of the pig is partly due to the increase in cyclic GMP formation through the stimulation of guanylate cyclase.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-1678711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-1714013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-1827660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-202268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-231208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-2447421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-2983811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-6112057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-6191133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-6297832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1327392-6306488
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
906-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1327392-Animals,
pubmed-meshheading:1327392-Coronary Vessels,
pubmed-meshheading:1327392-Cyclic GMP,
pubmed-meshheading:1327392-Dose-Response Relationship, Drug,
pubmed-meshheading:1327392-Niacinamide,
pubmed-meshheading:1327392-Nicorandil,
pubmed-meshheading:1327392-Nitroglycerin,
pubmed-meshheading:1327392-Pyridines,
pubmed-meshheading:1327392-Swine,
pubmed-meshheading:1327392-Vasodilation,
pubmed-meshheading:1327392-Vasodilator Agents
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pubmed:year |
1992
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pubmed:articleTitle |
Contribution of cyclic GMP formation to KRN2391-induced relaxation in coronary artery of the pig.
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pubmed:affiliation |
Pharmaceutical Research Laboratory of Kirin Brewery Co., Ltd., Gunma, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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