Linked Life Data

1325665

Source:http://linkedlifedata.com/resource/pubmed/id/1325665

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-10-6
pubmed:abstractText
Despite magnesium ions (Mg)'s widespread use for antiarrhythmic purposes, little is known concerning its antiarrhythmic mechanisms. We, therefore, examined Mg effects on delayed afterdepolarization (DAD), early afterdepolarization (EAD), triggered activity (TA) and aftercontraction (AC), using isolated ventricular cells and/or ventricular papillary muscle. In the experiments using the multicellular preparation, ACs were measured, with the use of a strain gauge. ACs were induced in isolated rat papillary muscle superfused with low K+ (0.5 mM) medium, after a train stimulation (2-5 Hz, 10-30 beats). In the experiments concerning cardiac myocytes, the effects of Mg on transient inward current (TI), which is responsible for DAD, were studied using a whole-cell voltage-clamp method applied on isolated guinea pig ventricular cells. And action potentials were also induced by current clamp (10 ms) and the effects of Mg on DAD, EAD and TA were examined. TI, DAD, EAD and TA were induced by use of pipette solution with high Ca2+ (0.7 mM) and low EGTA (0.1 mM).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0452-3458
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
677-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
[Antiarrhythmic effects of magnesium on single ventricular myocytes].
pubmed:affiliation
Department of Food and Nutrition, Nakamura Gakuen College.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't