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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1992-10-7
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pubmed:abstractText |
Ras proteins are membrane-associated transducers of eternal stimuli to unknown intracellular targets. The constitutively activated v-ras oncogene induces dedifferentiation in thyroid cells. v-Ras appears to act by stimulating protein kinase C (PKC), which inhibits the nuclear migration of the catalytic subunit of the cAMP-dependent protein kinase A (PKA). Nuclear tissue-specific and housekeeping trans-acting factors that are dependent on phosphorylation by PKA are thus inactivated. Exclusion of the PKA subunit from the nucleus could represent a general mechanism for the pleiotropic effects of Ras and PKC on cellular growth and differentiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:geneSymbol |
v-ras
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1621-30
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1325391-Animals,
pubmed-meshheading:1325391-Base Sequence,
pubmed-meshheading:1325391-Cell Differentiation,
pubmed-meshheading:1325391-Cell Line,
pubmed-meshheading:1325391-Cell Nucleus,
pubmed-meshheading:1325391-Cyclic AMP,
pubmed-meshheading:1325391-Down-Regulation,
pubmed-meshheading:1325391-Fluorescent Antibody Technique,
pubmed-meshheading:1325391-Molecular Sequence Data,
pubmed-meshheading:1325391-Oncogene Protein p21(ras),
pubmed-meshheading:1325391-Protein Kinase C,
pubmed-meshheading:1325391-Protein Kinases,
pubmed-meshheading:1325391-Rats,
pubmed-meshheading:1325391-Sphingosine,
pubmed-meshheading:1325391-Temperature,
pubmed-meshheading:1325391-Thyroid Gland
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pubmed:year |
1992
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pubmed:articleTitle |
v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A.
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pubmed:affiliation |
Dipartimento di Biologia e Patologia Molecolare e Cellulare, Universita di Napoli, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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