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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
Locomotor activity induced by d-amphetamine was found to be potentiated by food deprivation, a tryptophan-free diet, p-chlorophenylalanine and drugs proposed to antagonize serotonin receptors in brain. Administration of L-tryptophan 1 hour prior to d-amphetamine injection was found to antagonize the enhanced response to d-amphetamine in starved rats and in rats which had tryptophan removed from their diet. However, tryptophan did not block the potentiated response to d-amphetamine in animals pretreated with p-chlorophenylalanine. These findings suggested that the antagonism of d-amphetamine-induced activity by tryptophan in starved rats and rats fed a tryptophan-free diet was not due to a nonspecific depressant effect of the amino acid. Since accumulation of d-amphetamine and its metabolites was not affected by any of the treatments which enhanced its activity, it seems unlikely that an alteration in the metabolism of d-amphetamine can explain these findings. The present work provides additional support for the view that serotonergic fibers play an important role in the actions of d-amphetamine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-124375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-128026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-13320304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-13425249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-14013351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-14024202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-14078661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-14214434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4109535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4146741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4147065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4147726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4155993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4269051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4272776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4275348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4328018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4382310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4391062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4407107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4418151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4427983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4504832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4547673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4670860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4673401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4823644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4940440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4947255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-4985156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5077329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5113521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5456173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5472211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5560669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5567289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5581909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5664149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5789774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-5859253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/132524-6065144
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-3565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12-22
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:132524-Animals,
pubmed-meshheading:132524-Brain,
pubmed-meshheading:132524-Catecholamines,
pubmed-meshheading:132524-Dextroamphetamine,
pubmed-meshheading:132524-Diet,
pubmed-meshheading:132524-Fenclonine,
pubmed-meshheading:132524-Food Deprivation,
pubmed-meshheading:132524-Hydroxyindoleacetic Acid,
pubmed-meshheading:132524-Male,
pubmed-meshheading:132524-Motor Activity,
pubmed-meshheading:132524-Pargyline,
pubmed-meshheading:132524-Probenecid,
pubmed-meshheading:132524-Rats,
pubmed-meshheading:132524-Serotonin,
pubmed-meshheading:132524-Stimulation, Chemical,
pubmed-meshheading:132524-Tryptophan
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pubmed:year |
1976
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pubmed:articleTitle |
An inhibitory role for brain serotonin-containing systems in the locomotor effects of d-amphetamine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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