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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-9-25
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pubmed:abstractText |
Glutamate receptors are the principal excitatory neurotransmitter receptors in the central nervous system and are involved in a number of normal and pathological neuronal processes. Using subunit-specific antipeptide antibodies developed against the predicted amino acid sequences of several rat glutamate receptor cDNAs, we have identified these proteins in post-mortem human central nervous system tissue. Immunoblotting of dissected brain regions demonstrates that these receptor proteins are differentially distributed. The ability to identify these proteins in post-mortem human tissues should allow examination of the changes in levels of receptor subtypes that occur in a variety of neurological and psychiatric diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0364-5134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
680-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1325139-Adult,
pubmed-meshheading:1325139-Aged,
pubmed-meshheading:1325139-Aged, 80 and over,
pubmed-meshheading:1325139-Amino Acid Sequence,
pubmed-meshheading:1325139-Animals,
pubmed-meshheading:1325139-Antibody Specificity,
pubmed-meshheading:1325139-Central Nervous System,
pubmed-meshheading:1325139-Female,
pubmed-meshheading:1325139-Humans,
pubmed-meshheading:1325139-Immunoblotting,
pubmed-meshheading:1325139-Male,
pubmed-meshheading:1325139-Molecular Sequence Data,
pubmed-meshheading:1325139-Nerve Tissue Proteins,
pubmed-meshheading:1325139-Peptide Fragments,
pubmed-meshheading:1325139-Rats,
pubmed-meshheading:1325139-Receptors, AMPA,
pubmed-meshheading:1325139-Receptors, Glutamate,
pubmed-meshheading:1325139-Receptors, Neurotransmitter
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pubmed:year |
1992
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pubmed:articleTitle |
Immunological detection of glutamate receptor subtypes in human central nervous system.
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pubmed:affiliation |
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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