Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-9-25
|
| pubmed:abstractText |
To examine the ability of beta-adrenergic contractile reserve assessment to predict the outcome of patients with heart failure, a prospective study was undertaken in 35 patients with idiopathic dilated cardiomyopathy and radionuclide ejection fraction below 40%. During right- and left-sided catheterization, right atrial and left ventricular (LV) pressures, peak positive LV dp/dt, cardiac index, and plasma norepinephrine and epinephrine concentrations were measured at baseline. After a left main intracoronary infusion of dobutamine (25 to 200 micrograms.min-1), beta-adrenergic contractile responsiveness was assessed as the net increase in peak positive LV dp/dt (delta LV dp/dt). After the initial examination, patients were treated with diuretics, digitalis, and angiotensin converting enzyme inhibitors and then followed-up. After a mean follow-up period of 13 +/- 7 months, two groups of patients were distinguished: those who responded to medical therapy (group A, n = 26) and those with clinical deterioration (group B, n = 9) leading to death (n = 4) or heart transplantation (n = 5). Initial peak positive LV dp/dt, LV end-diastolic pressure, cardiac index, and LV ejection fraction were better in group A than in group B (p less than 0.001). Initial plasma norepinephrine and epinephrine concentrations were significantly higher and delta LV dp/dt was lower in group B than in group A (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
124
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
679-85
|
| pubmed:dateRevised |
2006-2-27
|
| pubmed:meshHeading |
pubmed-meshheading:1325107-Adult,
pubmed-meshheading:1325107-Cardiomyopathy, Dilated,
pubmed-meshheading:1325107-Dobutamine,
pubmed-meshheading:1325107-Epinephrine,
pubmed-meshheading:1325107-Female,
pubmed-meshheading:1325107-Follow-Up Studies,
pubmed-meshheading:1325107-Humans,
pubmed-meshheading:1325107-Male,
pubmed-meshheading:1325107-Middle Aged,
pubmed-meshheading:1325107-Multivariate Analysis,
pubmed-meshheading:1325107-Myocardial Contraction,
pubmed-meshheading:1325107-Norepinephrine,
pubmed-meshheading:1325107-Predictive Value of Tests,
pubmed-meshheading:1325107-Prognosis,
pubmed-meshheading:1325107-Prospective Studies,
pubmed-meshheading:1325107-Receptors, Adrenergic, beta,
pubmed-meshheading:1325107-Regression Analysis,
pubmed-meshheading:1325107-Stroke Volume,
pubmed-meshheading:1325107-Ventricular Function, Left
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Beta-adrenergic contractile reserve as a predictor of clinical outcome in patients with idiopathic dilated cardiomyopathy.
|
| pubmed:affiliation |
Département de Cardiologie, Centre Hospitalo-Universitaire Henri Mondor, Créteil, France.
|
| pubmed:publicationType |
Journal Article
|