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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1992-9-16
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pubmed:databankReference |
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pubmed:abstractText |
Here we describe an open reading frame (LMW23-NL) in the African swine fever virus genome that possesses striking similarity to a murine myeloid differentiation primary response gene (MyD116) and the neurovirulence-associated gene (ICP34.5) of herpes simplex virus. In all three proteins, a centrally located acidic region precedes a highly conserved, hydrophilic 56-amino-acid domain located at the carboxy terminus. LMW23-NL predicts a highly basic protein of 184 amino acids with an estimated molecular mass of 21.3 kDa. The similarity of LMW23-NL to genes involved in myeloid cell differentiation and viral host range suggests a role for it in African swine fever virus host range.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-14420403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-1656275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-1690380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-1826575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2154589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2156132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2173860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2197987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2207178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2281603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2325203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2327074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2339071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2389555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2515287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2555437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-2839602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-3023081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-3068966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-3245132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-3323821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-3893908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-4297621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-4563441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-4950035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-503860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-5540977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-6330085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-7063399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-7099970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-7108955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1323711-856945
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5586-9
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1323711-African Swine Fever Virus,
pubmed-meshheading:1323711-Amino Acid Sequence,
pubmed-meshheading:1323711-Animals,
pubmed-meshheading:1323711-Antigens, Differentiation,
pubmed-meshheading:1323711-Base Sequence,
pubmed-meshheading:1323711-Genes, Viral,
pubmed-meshheading:1323711-Genome, Viral,
pubmed-meshheading:1323711-Macrophages,
pubmed-meshheading:1323711-Molecular Sequence Data,
pubmed-meshheading:1323711-Proteins,
pubmed-meshheading:1323711-Reading Frames,
pubmed-meshheading:1323711-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1323711-Simplexvirus,
pubmed-meshheading:1323711-Species Specificity,
pubmed-meshheading:1323711-Swine,
pubmed-meshheading:1323711-Viral Proteins,
pubmed-meshheading:1323711-Virulence
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pubmed:year |
1992
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pubmed:articleTitle |
Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus.
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pubmed:affiliation |
Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York 11944.
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pubmed:publicationType |
Journal Article,
Comparative Study
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