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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
16
|
| pubmed:dateCreated |
1992-9-17
|
| pubmed:abstractText |
A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti-human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'-methyl-PMEG [(R)-3] and 2',2'-dimethyl-PMEG (7) demonstrated potent anti-HIV activity in the XTT assay with EC50 values of 1.0 and 2.6 microM, respectively. The corresponding (S)-2'-methyl-PMEG [(S)-3] was found to be less potent against HIV. In addition, the (R) and (S) enantiomers of 9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanine (HPMPG, 8) were prepared for comparison of biological activity, and shown to be active and equipotent against herpesviruses, but inactive against HIV.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
7
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2958-69
|
| pubmed:dateRevised |
2001-11-13
|
| pubmed:meshHeading |
pubmed-meshheading:1323678-Antiviral Agents,
pubmed-meshheading:1323678-Cell Line,
pubmed-meshheading:1323678-Guanine,
pubmed-meshheading:1323678-HIV,
pubmed-meshheading:1323678-Microbial Sensitivity Tests,
pubmed-meshheading:1323678-Organophosphorus Compounds,
pubmed-meshheading:1323678-Simplexvirus,
pubmed-meshheading:1323678-Stereoisomerism,
pubmed-meshheading:1323678-Structure-Activity Relationship
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.
|
| pubmed:affiliation |
Bristol-Myers Squibb Company, Pharmaceutical Research Institute, Wallingford, Connecticut 06492-7660.
|
| pubmed:publicationType |
Journal Article
|