Linked Life Data

1322787

Source:http://linkedlifedata.com/resource/pubmed/id/1322787

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pubmed-article:1322787pubmed:abstractTextIn this report we provide evidence for the activation of distinct differentiation pathways during treatment of the neuroblastoma cell line SMS-KCNR with 1 mM dibutyryl cyclic AMP (dbcAMP) and/or 5 microM retinoic acid (RA). Our results show that the adrenal gland specific gene pG2 is induced only during dbcAMP treatment, while RA induces a neuronal phenotype and expression of all neural related genes while decreasing the expression of many chromaffin related genes. Furthermore dbcAMP does not affect the DNA content distribution of SMS-KCNR [G1 = 61.8 +/- 4.1% (SD); S = 20.3 +/- 6.3%; G2-M = 18 +/- 5.4%] despite morphological and molecular signs of cellular differentiation. Conversely, RA arrests cell growth causing a decrease in cells in the growth fraction (S + G2 + M = 15.6 +/- 6.1%) and an increase in cells in G1 (G1 = 84.3 +/- 5%). Using cyclic AMP and RA in combination, we found that RA inhibited expression of adrenal gland specific gene pG2 and induced a neuronal phenotype. Since dbcAMP does not cause a significant G1 block in SMS-KCNR cells we propose that this agent may be able to induce SMS-KCNR only to an intermediate stage of chromaffin differentiation in which cells retain their proliferative potential.lld:pubmed
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pubmed-article:1322787pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:1322787pubmed:articleTitleIn vitro activation of distinct molecular and cellular phenotypes after induction of differentiation in a human neuroblastoma cell line.lld:pubmed
pubmed-article:1322787pubmed:affiliationMolecular Genetics Section, NIH-National Cancer Institute, Bethesda, Maryland 20892.lld:pubmed
pubmed-article:1322787pubmed:publicationTypeJournal Articlelld:pubmed
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