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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-8-28
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pubmed:databankReference |
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pubmed:abstractText |
Platelet-activating factor (PAF), a phospholipid, exhibits a variety of potent inflammatory bioactivities that are mediated by a specific cell surface receptor. The gene for the human PAF receptor (PTAFR) has been isolated by hybridization with a guinea pig probe. The coding sequence contains no intervening sequences. The encoded protein is highly homologous to the guinea pig PAF receptor (82% identity) and contains seven putative transmembrane domains. The PAF receptor therefore appears to be a member of the G protein coupled family of receptors and exhibits significant similarity to many members of the family. Analysis of somatic cell hybrids suggests that the PAF receptor is encoded by a single gene on human chromosome 1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:geneSymbol |
PTAFR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
832-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1322356-Amino Acid Sequence,
pubmed-meshheading:1322356-Base Sequence,
pubmed-meshheading:1322356-Chromosome Mapping,
pubmed-meshheading:1322356-Chromosomes, Human, Pair 1,
pubmed-meshheading:1322356-DNA,
pubmed-meshheading:1322356-DNA Probes,
pubmed-meshheading:1322356-Humans,
pubmed-meshheading:1322356-Introns,
pubmed-meshheading:1322356-Molecular Sequence Data,
pubmed-meshheading:1322356-Platelet Activating Factor,
pubmed-meshheading:1322356-Platelet Membrane Glycoproteins,
pubmed-meshheading:1322356-Receptors, Cell Surface,
pubmed-meshheading:1322356-Receptors, G-Protein-Coupled
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pubmed:year |
1992
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pubmed:articleTitle |
The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1.
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pubmed:affiliation |
ICOS Corporation, Bothell, Washington 98021.
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pubmed:publicationType |
Journal Article
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