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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1992-9-1
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pubmed:abstractText |
The effect of interferon gamma (IFN gamma) on the immunogenicity and immunosensitivity of mouse cell lines transformed by bovine papillomavirus type 1 (BPV1) DNA was examined in a syngeneic mouse model. The overnight incubation of BPV1-transformed cell lines with 100 IU/ml IFN gamma did not affect their ability to induce the generation of cytotoxic effector cells but it clearly increased their sensitivity to lysis by interleukin-2-induced lymphokine-activated killer (LAK) cells and by non-specific LAK-type effector cells induced by BPV-1-transformed cell lines. The treatment of two allogeneic lymphoid tumour cell lines, P815X2 and YAC-1, with IFN gamma either decreased or had no effect on their sensitivity to LAK-cell-mediated lysis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0340-7004
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
205-10
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1322243-Animals,
pubmed-meshheading:1322243-Bovine papillomavirus 1,
pubmed-meshheading:1322243-Cell Line, Transformed,
pubmed-meshheading:1322243-Cell Transformation, Neoplastic,
pubmed-meshheading:1322243-Cytotoxicity, Immunologic,
pubmed-meshheading:1322243-Interferon-gamma,
pubmed-meshheading:1322243-Interleukin-2,
pubmed-meshheading:1322243-Killer Cells, Lymphokine-Activated,
pubmed-meshheading:1322243-Male,
pubmed-meshheading:1322243-Mice,
pubmed-meshheading:1322243-Mice, Inbred C57BL
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pubmed:year |
1992
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pubmed:articleTitle |
Effect of interferon gamma on the sensitivity of bovine-papilloma-virus(BPV1)-transformed cell lines to cell-mediated cytotoxicity.
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pubmed:affiliation |
Department of Clinical Microbiology, University of Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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