| pubmed-article:1322123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C1515568 | lld:lifeskim |
| pubmed-article:1322123 | lifeskim:mentions | umls-concept:C0068138 | lld:lifeskim |
| pubmed-article:1322123 | pubmed:dateCreated | 1992-8-21 | lld:pubmed |
| pubmed-article:1322123 | pubmed:abstractText | Methyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP: phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de novo. | lld:pubmed |
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| pubmed-article:1322123 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1322123 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1322123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1322123 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1322123 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1322123 | pubmed:author | pubmed-author:EyoE EEE | lld:pubmed |
| pubmed-article:1322123 | pubmed:author | pubmed-author:ChoyP CPC | lld:pubmed |
| pubmed-article:1322123 | pubmed:author | pubmed-author:TardiP GPG | lld:pubmed |
| pubmed-article:1322123 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1322123 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1322123 | pubmed:volume | 285 ( Pt 1) | lld:pubmed |
| pubmed-article:1322123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1322123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1322123 | pubmed:pagination | 161-6 | lld:pubmed |
| pubmed-article:1322123 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1322123 | pubmed:meshHeading | pubmed-meshheading:1322123-... | lld:pubmed |
| pubmed-article:1322123 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1322123 | pubmed:articleTitle | The effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart. | lld:pubmed |
| pubmed-article:1322123 | pubmed:affiliation | Department of Biochemistry & Molecular Biology and Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada. | lld:pubmed |
| pubmed-article:1322123 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1322123 | pubmed:publicationType | In Vitro | lld:pubmed |
