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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1992-8-21
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pubmed:abstractText |
Methyl-lidocaine is an amphiphilic agent which has been used as an experimental anti-arrhythmic drug. When hamster hearts were perfused with labelled glycerol, the presence of methyl-lidocaine in the perfusate was found to enhance the labelling in phosphatidylserine, phosphatidylinositol, diacylglycerol and triacylglycerol. However, the labelling of phosphatidylcholine and phosphatidylethanolamine was not significantly changed by methyl-lidocaine treatment. Assays in vitro for the enzymes involved in the synthesis of neutral lipids and acidic phospholipids revealed that phosphatidate phosphatase and CTP: phosphatidate cytidylyltransferase activities were stimulated by methyl-lidocaine. The intracellular pool sizes of diacylglycerol and CDP-diacylglycerol were also elevated. We postulate that the enhanced syntheses of the neutral lipids and acidic phospholipids in the methyl-lidocaine-perfused heart were mediated via the direct activation of the key enzymes in the biosynthesis of these lipids de novo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-1107025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-1200988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-13641241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-173283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-192211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-200224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-213059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2158610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2222999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2550825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2663077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2822021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2822695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-2890641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-3029593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-3032105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-350877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-3756197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-3778529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-4046045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-4269073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-4425092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-507846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-5456034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-5485096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-560868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-5660480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-6089897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-6263339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-6267921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-6331400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-658442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-7002922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-952985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1322123-958324
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-acylglycerophosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Acyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Acyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Arrhythmia Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorpromazine,
http://linkedlifedata.com/resource/pubmed/chemical/Diacylglycerol O-Acyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Diglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol-3-Phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/N-methyllidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotidyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidate Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/phosphatidate cytidylyltransferase
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
285 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1322123-Acyl Coenzyme A,
pubmed-meshheading:1322123-Acyltransferases,
pubmed-meshheading:1322123-Animals,
pubmed-meshheading:1322123-Anti-Arrhythmia Agents,
pubmed-meshheading:1322123-Chlorpromazine,
pubmed-meshheading:1322123-Cricetinae,
pubmed-meshheading:1322123-Diacylglycerol O-Acyltransferase,
pubmed-meshheading:1322123-Diglycerides,
pubmed-meshheading:1322123-Glycerol-3-Phosphate O-Acyltransferase,
pubmed-meshheading:1322123-Heart,
pubmed-meshheading:1322123-Lidocaine,
pubmed-meshheading:1322123-Mesocricetus,
pubmed-meshheading:1322123-Myocardium,
pubmed-meshheading:1322123-Nucleotidyltransferases,
pubmed-meshheading:1322123-Phosphatidate Phosphatase,
pubmed-meshheading:1322123-Phospholipids,
pubmed-meshheading:1322123-Triglycerides
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pubmed:year |
1992
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pubmed:articleTitle |
The effect of methyl-lidocaine on the biosynthesis of phospholipids de novo in the isolated hamster heart.
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pubmed:affiliation |
Department of Biochemistry & Molecular Biology and Pharmacology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro
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