| pubmed-article:1321617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C0003236 | lld:lifeskim |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C1704973 | lld:lifeskim |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1321617 | lifeskim:mentions | umls-concept:C0059041 | lld:lifeskim |
| pubmed-article:1321617 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1321617 | pubmed:dateCreated | 1992-8-14 | lld:pubmed |
| pubmed-article:1321617 | pubmed:abstractText | Elsamicin A is an antitumor antibiotic with fascinating chemical structure and a good candidate for pharmaceutical development. Molecular mechanism of DNA backbone cleavage mediated by Fe(II)-elsamicin A has been examined. Product analysis using DNA sequencing gels and HPLC reveals the production of damaged DNA fragments bearing 3'-/5'-phosphate and 3'-phosphoglycolate termini associated with formation of free base. In addition, hydrazine-trapping experiments indicate that C-4' hydroxylated abasic sites are formed concomitant with DNA degradation by Fe(II)-elsamicin A. The results lead to the conclusion that the hydroxyl radical formed in Fe(II)-elsamicin A plus dithiothreitol system oxidizes the deoxyribose moiety via hydrogen abstraction predominantly at the C-4' carbon of the deoxyribose backbone and ultimately produces strand breakage of DNA. | lld:pubmed |
| pubmed-article:1321617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1321617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1321617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1321617 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1321617 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:1321617 | pubmed:author | pubmed-author:SugiuraYY | lld:pubmed |
| pubmed-article:1321617 | pubmed:author | pubmed-author:UesugiMM | lld:pubmed |
| pubmed-article:1321617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1321617 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1321617 | pubmed:volume | 186 | lld:pubmed |
| pubmed-article:1321617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1321617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1321617 | pubmed:pagination | 580-7 | lld:pubmed |
| pubmed-article:1321617 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:meshHeading | pubmed-meshheading:1321617-... | lld:pubmed |
| pubmed-article:1321617 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1321617 | pubmed:articleTitle | Product analyses in DNA strand scission by antitumor antibiotic elsamicin A. | lld:pubmed |
| pubmed-article:1321617 | pubmed:affiliation | Institute for Chemical Research, Kyoto University, Japan. | lld:pubmed |
| pubmed-article:1321617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1321617 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
