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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-8-11
|
| pubmed:abstractText |
In order to assess the potential role of the plasma membrane sodium-proton (Na+/H+) exchanger in the pathogenesis of diabetic nephropathy, we investigated 32 insulin dependent (type 1) diabetic patients and 21 control subjects. We tested the Na+/H+ exchange as the rate of amiloride sensitive and sodium dependent volume gain of platelets suspended in sodium propionate. Patients with diabetic nephropathy had significantly increased rates of Na+/H+ exchange (0.31 +/- 0.06 s-1 x 10(-2)) when compared to those without nephropathy (0.24 +/- 0.07, p less than 0.05) or to a control group (0.23 +/- 05, p less than 0.05). Nine patients who were classified as hypertensive had a highly significant increase in the Na+/H+ exchange rates when compared to 23 non-hypertensive diabetic patients: 0.33 +/- 0.04 versus 0.24 +/- 0.06 (p less than 0.001). There was no significant correlation between the Na+/H+ exchange rates and age, diabetes duration, glycated hemoglobin or fructosamine levels on the day of the test. In summary, the data presented here demonstrate an increase in the Na+/H+ exchange rate in insulin-dependent diabetic patients with nephropathy and hypertension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amiloride,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fructosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosamines,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Hydrogen Antiporter
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0300-8177
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-72
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1320732-Adolescent,
pubmed-meshheading:1320732-Adult,
pubmed-meshheading:1320732-Amiloride,
pubmed-meshheading:1320732-Blood Platelets,
pubmed-meshheading:1320732-Carrier Proteins,
pubmed-meshheading:1320732-Diabetes Mellitus, Type 1,
pubmed-meshheading:1320732-Diabetic Nephropathies,
pubmed-meshheading:1320732-Female,
pubmed-meshheading:1320732-Fructosamine,
pubmed-meshheading:1320732-Hemoglobin A, Glycosylated,
pubmed-meshheading:1320732-Hexosamines,
pubmed-meshheading:1320732-Humans,
pubmed-meshheading:1320732-Hypertension,
pubmed-meshheading:1320732-Hypertension, Renal,
pubmed-meshheading:1320732-Male,
pubmed-meshheading:1320732-Middle Aged,
pubmed-meshheading:1320732-Proteinuria,
pubmed-meshheading:1320732-Sodium,
pubmed-meshheading:1320732-Sodium-Hydrogen Antiporter
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Increased platelet sodium-proton exchange rates in insulin-dependent (type 1) diabetic patients with nephropathy and hypertension.
|
| pubmed:affiliation |
Department of Endocrinology, CHU Purpan, Toulouse, France.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|