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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-8-5
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pubmed:abstractText |
Mice with severe combined immunodeficiency (SCID) inoculated intraperitoneally with murine cytomegalovirus (MCMV) develop a wasting syndrome at 3-4 days and die at 6-9 days after the infection. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (DHPG, ganciclovir) and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were compared for their efficacy against MCMV-induced disease and mortality in SCID mice. Under all treatment conditions, i.e., administration of the test compounds for 5 consecutive days starting on the day of infection (day 0), for 5 consecutive days starting on day 4 after the infection, 2 periods of 3 consecutive days starting on day 0 and day 9 after infection, or as a single dose on day 3 before infection, HPMPC proved far superior to ganciclovir in delaying the onset of the disease and increasing the lifespan of the MCMV-infected mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytosine,
http://linkedlifedata.com/resource/pubmed/chemical/Ganciclovir,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/cidofovir
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0146-6615
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1320099-Animals,
pubmed-meshheading:1320099-Antiviral Agents,
pubmed-meshheading:1320099-Cytomegalovirus Infections,
pubmed-meshheading:1320099-Cytosine,
pubmed-meshheading:1320099-Disease Models, Animal,
pubmed-meshheading:1320099-Dose-Response Relationship, Drug,
pubmed-meshheading:1320099-Drug Administration Schedule,
pubmed-meshheading:1320099-Female,
pubmed-meshheading:1320099-Ganciclovir,
pubmed-meshheading:1320099-Male,
pubmed-meshheading:1320099-Mice,
pubmed-meshheading:1320099-Mice, SCID,
pubmed-meshheading:1320099-Organophosphorus Compounds,
pubmed-meshheading:1320099-Phosphonic Acids
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pubmed:year |
1992
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pubmed:articleTitle |
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for the treatment of murine cytomegalovirus infection in severe combined immunodeficiency mice.
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pubmed:affiliation |
Rega Institute for Medical Research, Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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