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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
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|
pubmed:dateCreated |
1992-7-29
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|
pubmed:abstractText |
We evaluated the effects of s.c. administration of naloxone in mice with streptozotocin-induced diabetes, compared to those in age-matched naive mice. Naloxone injected s.c. produced a dose-related increase in tail-flick latency in diabetic mice but not in naive mice. Naloxone-induced analgesia in diabetic mice was significantly reduced by pretreatment with naltrindole, a selective antagonist of delta-opioid receptors. These results indicate that naloxone-induced 'paradoxical' analgesia in diabetic mice may be mediated by delta-opioid receptors.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
|
|
pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
21
|
|
pubmed:volume |
210
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
339-41
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|
pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1319338-Analgesia,
pubmed-meshheading:1319338-Animals,
pubmed-meshheading:1319338-Diabetes Mellitus, Experimental,
pubmed-meshheading:1319338-Dose-Response Relationship, Drug,
pubmed-meshheading:1319338-Drug Interactions,
pubmed-meshheading:1319338-Indoles,
pubmed-meshheading:1319338-Injections, Subcutaneous,
pubmed-meshheading:1319338-Male,
pubmed-meshheading:1319338-Mice,
pubmed-meshheading:1319338-Mice, Inbred ICR,
pubmed-meshheading:1319338-Morphinans,
pubmed-meshheading:1319338-Naloxone,
pubmed-meshheading:1319338-Naltrexone,
pubmed-meshheading:1319338-Narcotic Antagonists,
pubmed-meshheading:1319338-Receptors, Opioid
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
Naloxone-induced analgesia in diabetic mice.
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|
pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article
|
